Thursday 25 April 2019
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Over 400 genes linked to schizophrenia discovered

Scientists have used artificial intelligence to discover 413 genes linked to schizophrenia across 13 brain regions, a finding that may pave way for therapies to treat the disorder. Examining gene expression at the tissue level allowed researchers to not only identify new genes associated with schizophrenia, but also pinpoint the areas of the brain in which abnormal expression might occur. In the largest study of its kind, researchers applied a novel machine learning method to data from more than 100,000 people. While affecting less than two per cent of the global population, schizophrenia is one of the leading causes of disability worldwide. Despite its low prevalence, the disease has major public health and socioeconomic impact, primarily due to hospital readmission and treatment costs. While it is widely believed that numerous genes contribute to increased risk of schizophrenia development, the exact genetic underpinnings are poorly understood. Nonetheless, such ambiguity serves as .


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